Streblus asper attenuates stress-induced physical and Biochemical changes in Rat Model

Abstract

The study deals with the evaluation of Streblus asper hydroalcoholic extract for adaptogenic activity using swimming endurance test and milk induced leukocytosis. The Streblus asper hydroalcoholic extract was administered to control vehicle, extract-treated (200 and 400 mg/kg p.o.) and standard drug (diazepam) treated groups prior to 1 hour of stress methods for 7 consecutive days. Mean swimming time, brain tissue antioxidant profiles (MDA, SOD, GSH, and Catalase), triglyceride, creatinine kinase, and corticosterone were evaluation parameters of adaptogenic activity in the swimming endurance test. However, determination of difference in number of leukocyte count considered as evaluation parameter was using milk induced leukocytosis method. The dose 400 mg/kg p.o. of Streblus asper hydroalcoholic extract for adaptogenic activity in both stress method showed significant variation (P< 0.1) when is compared with the stress control group. Therefore, it was revealed that Streblus asper hydroalcoholic extract showed potential adaptogenic activity.