Adaptogenic effect of the ethanol extract of mangosteen peel (Garcinia mangostana L.) in mice (Mus musculus) blood profile using the Swimming Endurance Test

Abstract

The adaptogenic activity was related to antioxidant activity, which can reduce the number of free radicals, and in turn, will reduce stress and improve body balance. Mangosteen rind (Garcinia mangostana L.) with a large antioxidant content promises to be Adaptogen. This study was aimed to examine the Adaptogenic effects of ethanol extract of mangosteen peel (Garcinia mangostana L.) Using the Swimming Endurance Test (SET) in mice. Simplicia of mangosteen Fruit (Garcinia mangostana L.) extracted by maceration using 96% ethanol, then tested for its Adaptogenic activity based on swimming endurance test and routine serum blood profile of mice including blood glucose, RBC and WBC count in five treatment groups. The groups consisted of negative control of NaCMC 1%, positive control of Vit C. 100 mg/kg BW and three groups treatment of ethanol extract of mangosteen peel (Garcinia mangostana L.) ranging from 100, 200 and 400 mg/kg BW. All groups were given treatments once daily per-oral for seven days, further on the 8th day, a SET test and blood serum profile test were performed. The results showed that the ethanol extract of mangosteen peel (Garcinia mangostana L.) had the ability to be Adaptogenic. The RBC count and WBC count showed normal value after stress induction by SET. The adaptogenic of mangosteen peel extract reduced the increase in blood glucose level after mice experienced significant stress.