STRATIFICATION OF NEPHROCEREBRAL AND CARDIOVASCULAR RISK IN CHRONIC GLOMERULONEPHRITIS (LITERATURE REVIEW)

I T Murkamilov,K A Aitbaev,V V Fomin,N A Redzhapova,F A Yusupov,A I Sabirova,B Zh Imanov,Zh A Murkamilova,I S Sabirov

doi:10.20514/2226-6704-2018-8-6-418-423

I T Murkamilov, K A Aitbaev + Show 7 more

Open Access

https://doi.org/10.20514/2226-6704-2018-8-6-418-423

Copy DOI

Abstract

This article analyzes the literature data concerning the origin and progression of cerebrovascular and cardiac diseases in renal dysfunction. Cardiovascular diseases and chronic kidney disease have common “traditional” risk factors, while the population growth in patients with renal impairment is currently mainly due to secondary renal damage in socially important diseases such as obesity, hypertension, atherosclerosis, type 2 diabetes, ischemic heart disease and chronic heart failure. The presented data of scientific researches testify to the direct correlation correlation between the decrease of the renal function and the increased risk of cardioand cerebrovascular diseases and death, irrespective of other risk factors. Obesity and associated biological substrates are independent risk factors for persistent impairment of kidney function and an increase in the body mass index causes direct damage to the kidneys, due to the disrupted synthesis of fat cytokines by various cytokines with nephrotoxic action, and also mediated — by inducing the development of diabetes mellitus 2 type and arterial hypertension, which are the most frequent risk factors for chronic kidney disease and cardiovascular diseases. The presented data on the role of endothelial dysfunction in impaired renal function, which contributes to the formation of atherosclerosis, and the increase in the severity of the atherosclerotic process contributes to an increase in the sever ity of renal failure. Literature data on the value of the heart rate are also presented. The increase in the heart rate can lead to atherosclerotic densification of the arteries, which is associated with an increase in the rate of spread of the pulse wave with a violation of the mechanisms of autoregulation of the blood flow in the brain and kidneys.

Highlights

STRATIFICATION OF NEPHRO-CEREBRAL AND CARDIOVASCULAR RISK IN CHRONIC GLOMERULONEPHRITIS (LITERATURE REVIEW)
The presented data of scientific researches testify to the direct correlation correlation between the decrease of the renal function and the increased risk of cardio- and cerebrovascular diseases and death, irrespective of other risk factors
The presented data on the role of endothelial dysfunction in impaired renal function, which contributes to the formation of atherosclerosis, and the increase in the severity of the atherosclerotic process contributes to an increase in the severity of renal failure

Summary

Introduction

STRATIFICATION OF NEPHRO-CEREBRAL AND CARDIOVASCULAR RISK IN CHRONIC GLOMERULONEPHRITIS (LITERATURE REVIEW). АГ — артериальная гипертензия, АСБ — атеросклеротической бляшки, ГЛЖ — гипертрофия левого желудочка, ИБС — ишемическая болезнь сердца, ИМ — инфаркт миокарда, ИМТ — индекс массы тела, ЛП — левое предсердие, МИ — мозговой инсульт, МРТ — магнитнорезонансная томография, СД — сахарный диабет, СКФ — скорость клубочковой фильтрации, ССЗ — сердечно-сосудистые заболевания, ССО — сердечно-сосудистые осложнения, ТКИМ — толщина комплекса интима-медиа, ФВ ЛЖ — фракция выброса левого желудочка, ФП — фибрилляция предсердий, ФР — факторы риска, ХБП — хроническая болезнь почек, ХГН — хронический гломерулонефрит, ХМ ЭКГ — холтеровское мониторирование электрокардиограммы, ХС — холестерин,ЦВЗ — цереброваскулярные заболевания, ЦВЗ — цереброваскулярные заболевания, ЧСС — частота сердечных сокращений

Results

Conclusion