PS 11-79 METABOLIC SYNDROME, INSULIN RESISTANCE IS ASSOCIATED WITH RAPID DECLINE OF KIDNEY FUNCTION AND INCIDENT CHRONIC KIDNEY DISEASE OVER 10 YEARS IN THE KOREAN GENOME AND EPIDEMIOLOGY STUDY (KoGES)

Abstract

Objective: Although metabolic abnormalities have been considered as important risk factor for chronic kidney disease (CKD), the impact of metabolic syndrome (MetS)/insulin resistance on renal function deterioration is poorly understood. Furthermore, sex differences in this relationship have not been fully evaluated. The aim of this study was to investigate the sex-specific association between MetS and incident CKD/rapid decline of estimated glomerular filtration rate (eGFR) in a 10-year prospective, population-based study of Koreans. Design and Method: Among 10,030 subjects, 6089 (age range 40–69 years) without history of CKD and cardiovascular disease at baseline were analyzed using data generated from rural and urban areas during 2001–2010. They were categorized into two groups on the basis of the presence of MetS at baseline. Incident CKD was defined as eGFR <60 ml/min per 1.73 m2 and rapid decline of eGFR was defined as >3 ml/min per 1.73 m2 /yr. Results: Among 10,030 subjects, 6089 (age range 40–69 years) without history of CKD and cardiovascular disease at baseline were analyzed using data generated from rural and urban areas during 2001–2010. They were categorized into two groups on the basis of the presence of MetS at baseline. Incident CKD was defined as eGFR <60 ml/min per 1.73 m2 and rapid decline of eGFR was defined as >3 ml/min per 1.73 m2 /yr. Conclusions: MetS and insulin resistance were an independent risk factor for incident CKD in relatively healthy Korean population. The MetS-CKD relationship was more prominent in men than in women. Our findings suggest the importance of detection and treatment of MetS and insulin resistance as a strategy to prevent CKD in clinical practice.