Abstract
Bisphenol A (BPA), also known as 2,2,-bis(4-hydroxyphenyl) propane, is a common component of plastics worldwide. However, it has been shown to act as an endocrine disruptor with some hormonal functions. Furthermore, high levels of BPA have been related to the development of cardiovascular events and the activation of carcinogenesis pathways. Patients with chronic kidney disease (CKD) have higher serum concentrations of BPA due to their impaired renal function. This situation is aggravated in CKD patients requiring dialysis, because the BPA content of dialysis devices (such as, for example, the filters) is added to the lack of excretion. In addition to the development of BPA-free dialysis filters, some techniques can contribute to the reduction of BPA levels in these patients. The aim of this review is to illustrate the impact of BPA on dialysis patients and suggest some strategies to reduce its inherent risks.
Highlights
IntroductionBisphenol A (BPA), known as 2,2,-bis(4-hydroxyphenyl) propane, is a common component of synthetic polycarbonate plastics and epoxy resins (Figure 1)
The aim of the present review is to summarise the evidence of kidney-induced Bisphenol A (BPA) injury and the potential for attenuating the accumulation of this compound in dialysis patients
In population-based studies, BPA levels have been shown to be inversely correlated to kidney function, with maximum levels observed in dialysis-dependent patients [13]
Summary
Bisphenol A (BPA), known as 2,2,-bis(4-hydroxyphenyl) propane, is a common component of synthetic polycarbonate plastics and epoxy resins (Figure 1)
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