Abstract
Although there is continuous work in progress in some of the above mentioned approaches, but there is still no drug/vaccine available to treat COVID-19 Drug repurposing offers an economical and rapid strategy to discover a potential therapeutic agent in the current hectic situation This compilation may be helpful to the researchers, drug developers and health agencies to look into the matter and work against the possible targets to develop a therapeutic candidate against COVID-19 The challenge associated with drug repurposing is the inadequate efficacy of single therapeutic candidate Another complication associated with this approach is to search and analyze the huge amount of previously reported data to make efficient and effective use against a new indication The complex/unclear events of the pathophysiology of SARS-CoV-2 also offer a great challenge to select a candidate for repurposing
Highlights
The terrible story of the coronavirus disease (COVID-19) needs no introduction in the present hour
The history justifies this fact of viral epidemics, such as SARS-CoV prevailed during 2002-2003, H1N1 during 2009, MERS-CoV in 2012 and the most dreadful COVID-19 from December 2019 to till date [1]
A huge number of research groups from all parts of the world are continuously working in order to develop therapeutic agents against COVID-19, but no vaccine or therapeutic candidate has been developed to date
Summary
The terrible story of the coronavirus disease (COVID-19) needs no introduction in the present hour. It is evident that viral diseases have always appeared as a mystery and are the fatal ailments in human beings The history justifies this fact of viral epidemics, such as SARS-CoV prevailed during 2002-2003, H1N1 during 2009, MERS-CoV in 2012 and the most dreadful COVID-19 from December 2019 to till date [1]. This ailment has emerged as a wonderstruck and put the whole world in worry and confusion. Coronaviruses (CoVs) are the major microorganisms causing fatal respiratory disease outbreaks worldwide. Other HCoVs are severe acute respiratory syndrome causing coronavirus (SARS-CoV), SARS-CoV-2 and the Middle East respiratory syndrome causing the coronavirus (MERS-CoV), which can cause epidemics with severe respiratory manifestations [6]
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