Abstract
Stopping cells from dividing.
Highlights
In a recent report published in Oncotarget, three genes important for cell cycle regulation have been shown to be controlled by the p53-p21Cyclin/CDK-DREAM-CDE/CHR pathway [5]
Survivin (BIRC5), CDC25C, and PLK1 represent genes that had been previously examined in several reports for their transcriptional control during the cell cycle and in regard to their response to p53 activation [5]
Mammalian DREAM was discovered because of its role in transcriptional repression of cell cycle genes. It is composed of the MuvB core complex, E2F4/DP, and the pRB-related p130 protein [6]
Summary
In a recent report published in Oncotarget, three genes important for cell cycle regulation have been shown to be controlled by the p53-p21Cyclin/CDK-DREAM-CDE/CHR pathway [5]. Survivin (BIRC5), CDC25C, and PLK1 represent genes that had been previously examined in several reports for their transcriptional control during the cell cycle and in regard to their response to p53 activation [5]. The current report resolves these issues and presents a consistent mechanism of indirect transcriptional repression by p53 for Survivin, CDC25C, and PLK1 through the p53-DREAM axis [5]. The DREAM complex is involved in p53mediated transcriptional repression.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
