Abstract
A method of stop-flow analysis is described for use in man. The results show reproducible distribution patterns of electrolyte and inulin concentrations which are thought to be representative of different parts of the nephron. Characteristic changes of the pattern were observed after the application of furosemide as well as after administration of a mercurial diuretic: furosemide acts mainly on the sodium reabsorption of the loop of Henle and the early distal tubule, whereas the mercurial diuretic has its main effect on the sodium reabsorption of the proximal tubule. The method is easily performed and does not cause any undue discomfort to the patient.
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