Abstract

: Stokesia laevis (common name Stokes aster) ethanolic extract (Slae26) containing 5 mg GAE/mL extract was investigated to establish cytotoxicity and anti-proliferative effects. The assays were performed on normal murine fibroblast cell line L929 and malignant murine melanoma cell line B16, respectively; for the first time in literature data, potential cytotoxic and anti-proliferative effects of the ethanolic extract from S. laevis on both, normal murine fibroblast cell line L929, and murine melanoma cell line B16 have been proved. The study is supplemented by molecular docking simulations of the major components of Slae26 against human tyrosinase receptor, to evaluate possible melanogenesis inhibition.

Highlights

  • According to the specialized data, the cutaneous malignant melanoma is the most aggressive type of skin cancer [1]

  • Aiming to extend the authors’ previously published work [5], the present paper aims to study the cytotoxic and anti-proliferative potential of the standardized ethanolic extract (Slae26) from Stokesia laevis

  • Asteraceae), 5 mg GAE/mL extract, on normal murine fibroblast cell line L929 and malignant murine melanoma cell line B16, respectively; the predominant compounds in Slae26 (HPTLC analysis) are caffeic acid and luteolin derivates [5]

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Summary

Introduction

According to the specialized data, the cutaneous malignant melanoma is the most aggressive type of skin cancer [1]. Data indicate that the skin melanoma is the most commonly occurring cancer worldwide; the most affected are Australian and New. Zealand peoples, followed by Caucasian peoples [2]. Due to high aggressiveness and chemical therapy resistance [3], there are many attempts to find new therapy combinations and antitumor agents or synergistic compounds able to fight against skin melanoma cancer resistance. Asteraceae), 5 mg GAE/mL extract, on normal murine fibroblast cell line L929 and malignant murine melanoma cell line B16, respectively; the predominant compounds in Slae (HPTLC analysis) are caffeic acid and luteolin derivates [5]

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