Stochastic Turing Pattern Formation in a Model with Active and Passive Transport.

Abstract

We investigate Turing pattern formation in a stochastic and spatially discretized version of a reaction-diffusion-advection (RDA) equation, which was previously introduced to model synaptogenesis in C. elegans. The model describes the interactions between a passively diffusing molecular species and an advecting species that switches between anterograde and retrograde motor-driven transport (bidirectional transport). Within the context of synaptogenesis, the diffusing molecules can be identified with the protein kinase CaMKII and the advecting molecules as glutamate receptors. The stochastic dynamics evolves according to an RDA master equation, in which advection and diffusion are both modeled as hopping reactions along a one-dimensional array of chemical compartments. Carrying out a linear noise approximation of the RDA master equation leads to an effective Langevin equation, whose power spectrum provides a means of extending the definition of a Turing instability to stochastic systems, namely in terms of the existence of a peak in the power spectrum at a nonzero spatial frequency. We thus show how noise can significantly extend the range over which spontaneous patterns occur, which is consistent with previous studies of RD systems.