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Abstract
Cell proliferation is of great importance for survival of multicellular organisms. In normal tissues cell division is strictly regulated to maintain normal proliferative balance and diminish the risk of malignant transformation. Higher organisms contain two mechanisms that control normal cell proliferation, apoptosis and senescence. Gradual telomere shortening with each cell division is considered as the main cause of cell senescence. Further analysis indicate the existence of additional mechanism of telomere shortening which could involve generation of extrachromosomal circular telomeric DNA (t-circles) as a result of abrupt telomere shortening causing sudden appearance of senescent cells in growing cultures. This mechanism ensures heterogeneity in growth potential among individual cells, which is crucial for gradual progression of aging process. Also, telomere damage plays an important role in non-dividing post-replicative cells.
Published Version
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