Abstract
Endogenous DNA breaks: γH2AX and the role of telomeres
Highlights
DNA double-strand breaks (DSBs) rarely form in living cells but can be deadly
This discovery revolutionized the ability to detect DSBs and provided a unique tool to examine processes involved in DNA damage signalling
In most normal primary human cells, γH2AX foci are relatively rare so that DSBs can be detected by nonlethal radiation doses in the mGy range [5]
Summary
DNA double-strand breaks (DSBs) rarely form in living cells but can be deadly. A single unrepaired DSB will kill a yeast cell deficient in recombination [1]. As physical methods lack the sensitivity to confirm that these foci signify true breaks, the possibility remains that either some tumor cells contain large numbers of DSBs or there are other explanations for endogenous foci. In this issue of Aging, Nakamura et al examine the possibility that endogenous foci in tumor cells are associated with telomeres.
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