Abstract
The dynamics of proteins in cell membranes is governed by a quasi 2D hydrodynamics, in which flows in the membrane couple to flows in the bulk solvent in contact with the membrane. A computationally expedient method for modeling solvent hydrodynamics has been interfaced with the Dry MARTINI solvent free lipid model. The combination of particle-based, chemically detailed lipid and protein models with solvent hydrodynamics offers a route to quantitative simulations of protein dynamics in complex membrane environments. The method is validated by reproducing known theoretical results for low Reynolds number hydrodynamics. Results for the dynamics of lipid translational diffusion, membrane undulations, and membrane protein diffusion will be presented.
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