Abstract
This work reports the synthesis of a biocompatible, pH sensitive 2-Hydroxy Ethyl Methacrylate-g-Soy protein Isolate (HEMA-g-SPI) hydrogel for controlled drug release applications. HEMA-g-SPI hydrogel was prepared by grafting HEMA onto SPI through in-situ free radical polymerization under an inert atmosphere and was optimized for reaction variables such as initiator concentration, reaction time, monomer concentration, SPI concentration to achieve high swelling capacity. The grafted hydrogel was analyzed through FTIR, TGA, SEM and a detailed mechanism for HEMA-g-SPI hydrogel formation is proposed. The equilibrium swelling, mechanism, and kinetics of model drug, paracetamol release has been studied at pH condition of gastric fluid and intestinal fluid i.e., 1.2 and 7.4 respectively at 37 °C. The hydrogel exhibits pH sensitivity with equilibrium swelling being quite slow at pH 1.2 as compared to at pH 7.4 with cumulative drug release (~30%) at pH 1.2, which is increased to ~70% at pH 7.4. The results revealed that HEMA-g-SPI hydrogel is non-cytotoxic and has potential for controlled drug release in gastrointestinal tract.
Published Version
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