Abstract
The topic of stimuli-responsive nanocarriers for loading guest molecules is dynamic. It has been widely studied in applications including drug controlled release, smart sensing, catalysis, and modeling. In this paper, a graft copolymer (hyperbranched polystyrene)-g-poly[2-(dimethylamino)ethyl methacrylate] (HBPS-g-PDMAEMA) was synthesized and characterized by 1H NMR and GPC. It was observed that the star-like HBPS-g-PDMAEMA formed aggregates in aqueous solution. The influence of polymer concentration, ionic strength and pH value on the aggregates in aqueous solution was investigated by using UV–vis spectroscopy and DLS analysis. The results showed that size of aggregates was affected by a corresponding stimulus. In addition, the loading ability of HBPS-g-PDMAEMA aggregates was investigated by using pyrene or Nile red as the model guest molecules by using UV–vis and fluorescence spectroscopy. The results showed that HBPS-g-PDMAEMA aggregates were capable to encapsulate small hydrophobic molecules. These newly prepared HBPS-g-PDMAEMA nanocarriers might be used in, e.g., medicine or catalysis.
Highlights
Stimuli-responsive polymers have attracted much attention due to their broad applications including drug controlled release [1,2,3,4,5], sensing [6,7] and 4D printing [8,9]
For atom transfer radical self-condensing vinyl polymerization (AT-SCVP), the polymerization was initiated by benzyl chloride of vinylbenzyl chloride (VBC)
The results of 1H NMR and gel permeation chromatography (GPC) measurements showed that the target polymer Hyperbranched polystyrene (HBPS)-g-Poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) was successfully prepared
Summary
Stimuli-responsive polymers have attracted much attention due to their broad applications including drug controlled release [1,2,3,4,5], sensing [6,7] and 4D printing [8,9]. The results of 1H NMR and GPC measurements showed that the target polymer HBPS-g-PDMAEMA was successfully prepared.
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