Abstract
The development of contact sensitivity (CS) to picryl chloride in mice was enhanced by injection of moderate doses of allogeneic spleen cells, whereas large numbers of cells had a suppressive effect in comparison to the lower doses. Parental spleen cells were also found to enhance the development of CS in Fl hybrid mice. Allogeneic thymus cells did not significantly stimulate the development of CS. The possibility that these findings reflect interactions between T cells during the immune response is discussed.
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