Abstract
In intact immature female rats, ovarian progesterone levels were significantly elevated 1 h after iv injection of either LH (NIH-LH-B8, 10 μg) or FSH (NIH-FSH-S11; 100 μg). Testosterone treatment (5 mg daily, sc) for 3 consecutive days enhanced this ovarian progesterone response to LH or to FSH. 17β-Estradiol (1 mg daily for 3 days) had no effect on stimulation of ovarian progesterone production by LH. Although 17β-estradiol slightly enhanced ovarian progesterone levels in response to FSH stimulation, its effect was significantly less than that of testosterone. By contrast, 17β-OH-5α-androstan-3-one (DHT), when administered systemically (10 mg, sc), had no effect on the ovarian responsiveness to either LH or FSH. However, when DHT was administered by means of Silastic minicapsules implanted locally, ovarian progesterone response to FSH, but not LH, was significantly enhanced when compared to the response in controls. A stimulatory action of androgens on the ovary could be explained, at least in part, by t...
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