Abstract
Several antiviral acyclic nucleotide analogues activate expression of genes for cytokines, such as TNF-α, IL-10 in macrophages and IFN-γ in splenocytes. This is an underlying mechanism for substantially enhanced production of nitric oxide generated by IFN-γ. More lipophilic prodrugs, bis-POM-PMEA and bis-POC-PMPA, are cytocidal for macrophages and thus inhibit nitric oxide formation.
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