Abstract
Objective: Quantitative studies were performed to investigate liver-specific uptake of the microbubble Levovist®, using stimulated acoustic emission (SAE), which can detect microbubbles even when stationary or slow moving. It is well known that in the progressing state of liver disease, such as liver cirrhosis, there are arterialization of the liver; formation of intrahepatic shunts between the branches of the hepatic artery, the portal vein, and the hepatic veins; pulmonary arteriovenous shunts; and a hyperdynamic circulatory state with increased cardiac output and reduced systemic vascular resistance. The aim of this investigation using an ultrasound contrast agent was to assess whether those changes in circumstance of liver parenchymal flow were able to be determined or not.
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