Abstract
Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils.
Highlights
IntroductionPhylum Cnidaria) comprises large quantities of terpenoid [1,2] and steroid [3,4] analogues, which often have complex structures and biological activities
The octocoral Nephthea columnaris (Studer, 1895) comprises large quantities of terpenoid [1,2] and steroid [3,4] analogues, which often have complex structures and biological activities
In vitro anti-inflammatory activity assays were performed using human neutrophils, and the results demonstrated that sterol 3 had inhibitory effects on the generation of superoxide anions and the release of elastase, with IC50 values of 4.60 and 3.90 μM, respectively, but sterol 4 displayed no anti-inflammatory effects (Table 3)
Summary
Phylum Cnidaria) comprises large quantities of terpenoid [1,2] and steroid [3,4] analogues, which often have complex structures and biological activities. In continuing studies of the constituents of N. columnaris collected from the southern waters off the coast of Taiwan, two new sterols, columnaristerols B (1) and C (2), and known analogues, 5,6-epoxylitosterol (3) and litosterol (4) [5]. Sterol 3 was found to inhibit the production of superoxide anions and release of elastase by human neutrophils. Mar. Drugs 2017, 15, 212; doi:10.3390/md15070212 www.mdpi.com/journal/marinedrugs
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