Steroidal glycosides from Hoodia gordonii

Abstract

Ten new C 21-steroidal derivatives, namely gordonosides A–L ( 1–10) were isolated from a chloroform extract of the aerial parts of Hoodia gordonii, a plant widely used in the nutraceutical market as an ingredient of weight loss supplements. Compounds ( 2–10) are based on 3β,14β-dihydroxy-pregn-5-en-17-βone aglycone ( 1). Their structures were characterized on the basis of HR-MS spectrometry and both 1D and 2D NMR techniques.