Abstract
Tissue samples from 20 patients with nonepithelial ovarian malignancies were assayed for cytosol estrogen (ER c) and in selected samples progestin-receptor (PR c) proteins. The nine germ cell malignancies assayed were low in ER c. One recurrent granulosa cell tumor had an ER c concentration of 36 fmole/mg cytosol protein (fmole/mg c.p.) while three other stromal tumors were low in ER c. Three of seven mixed mesodermal tumors had a high ER c concentration (34–91 fmole/c.p.). Two primary and one recurrent granulosa cell tumors and one endodermal sinus tumor had borderline to elevated PR c levels (18–254 fmole/c.p.). Four of seven mixed mesodermal tumors had borderline to slightly elevated PR c concentrations (13–22 fmole/c.p.). The low ER c in germ cell malignancies of the ovary is consistent with previous clinical observations that the growth of these tumors is not influenced by removal of the contralateral ovary. The high ER c levels detected in three of seven mixed mesodermal ovarian tumors and one of three granulosa cell tumors suggest that hormone-related therapy should be investigated in the management of patients with these malignancies.
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