Abstract
The saturation of the C-4,5 double bond of Δ 4-3-ketosteroids catalyzed by Δ 4-3-ketosteroid-5β-reductase has been shown to involve a hydride ion transfer from the A-position of NADPH to the 5β-position of the steroid while the reaction catalyzed by Δ 4-3-ketosteroid-5α-reductase involves a hydride transfer from the B-position of NADPH to the 5α-position of the steroid. Thus, this study shows that Δ 4-5β-reductase has A-stereospecificity while Δ 4-5α-reductase has B-stereospecificity.
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