Abstract
The addition of copper reagents prepared by transmetalation from polyfunctional organozinc iodides to reactive alkynes such as 1-(methylthio)-1-hexyne, phenylacetylene and acetylene, leads to stereochemically well-defined (syn addition), highly functionalized alkenylcopper reagents that after protonation, allylation, iodolysis, or stannylation afford stereochemically pure di-, tri-, and tetrasubstituted olefins. A similar intramolecular carbocupration has allowed the preparation of highly substituted five-membered carbocycles. Compared to lithium-or magnesium-copper reagents, the highly functionalized copper reagents can contain an ester, nitrile, or chloride function. However, they display a lower reactivity than the lithium- or magnesium-copper reagents and do not react with unactivated terminal alkynes
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.