Abstract
Abstract A new and highly stereoselective synthesis of the C1-C7 segment of (+)-discodermolide, the marine natural product having the potent immunosuppressive activity, is described in which the stereospecific methylation of γ,δ-epoxy acrylate with trimethylaluminum and the intramolecular conjugate addition of an acetal alkoxide anion are involved as key steps.
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