Abstract
AbstractMultifunctionalized 1,2,4‐triazolidines have been synthesized by a ruthenium porphyrin‐catalyzed three‐component coupling reaction. In a one‐pot reaction, ruthenium porphyrins catalyzed the in situ generation of azomethine ylides from α‐diazo esters and imines. Stereoselective 1,3‐dipolar cycloaddition reactions of the azomethine ylides with dialkyl azodicarboxylates gave the corresponding 1,2,4‐triazolidines in good yields (up to 85 %). Using chiral 8‐phenylmenthanol α‐diazo ester as the carbenoid source, chiral 1,2,4‐triazolidines have been obtained with good diastereoselectivity (up to 84 % de). Some of the 1,2,4‐triazolidines exhibited good cytotoxicity against human nasopharyngeal carcinoma (SUNE1) (IC50=10.4 μM) and human cervical carcinoma (Hela) (IC50=10.7 μM) cell lines.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
