Stereoselective Synthesis of Less Accessible α-Tertiary Amino Ketimines via Electrophilic Amination of α-Branched N-tert-Butanesulfinyl Ketimines

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A stereocontrolled electrophilic amination of α-branched N-tert-butanesulfinyl ketimines was developed to construct α-aminoketone derivatives containing less accessible α-tetrasubstituted stereocenters. Stereospecific α-deprotonation of ketimines with potassium tert-butoxide gave stereodefined metalloenamine intermediates that could act as nucleophiles to attack azodicarboxylic derivatives, affording α-aminated products in high yields with excellent stereoselectivities.