Abstract
Combining coordination chemistry and peptide engineering offers extraordinary opportunities for developing novel molecular (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the stereoselective assembly of designed peptides containing 2,2′-bipyridine ligands into parallel three-stranded chiral peptide helicates, and that these helicates selectively bind with high affinity to three-way DNA junctions.
Highlights
Peptides are ideal platforms for the programmed assembly of supramolecular structures, as they encode in their sequences precise structural and functional information in their sequence
One of the biggest challenges for the synthesis of helicates is their stereoselective assembly with controlled supramolecular chirality.[31−34] In this context, we wanted to test whether a small trimeric peptide motif could effectively control the selfassembly of three-stranded peptide helicates, selecting a particular orientation of the ligand chains and helical chirality
In contrast to our previous approach to helicate synthesis relying on the folding of a single peptide chain,[35,36] here we would rely on the assembly of three independent peptide monomers to template the formation of the desired helicate
Summary
Financial support from the Spanish grant RTI2018-099877-BI00, the Xunta de Galicia (Centro singular de Investigación de Galicia accreditation 2016−2019, ED431G/09, and ED431B 2018/04), and the European Union (European Regional Development Fund - ERDF) is gratefully acknowledged. J.G.G. thanks the Spanish MINECO for his FPI fellowship. D.B. thanks the CIQUS for his 2018 PhD fellowship. G.S. and J.D.M. thank Spanish MINECO (grant CTQ2017-87889-P) and Generalitat de Catalunya (2017SGR1323) for the financial support. Kazunori Matsuura at Tottori University for his valuable input during the preparation of this manuscript
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
