Abstract
One-pot method for direct stereoselective (S)-α-thioalkylation of glycine in Ni(II) coordination environment was elaborated. The reaction of electrochemically deprotonated Ni(II) glycine/Schiff-base complex containing (S)-o-[N-(N′-benzylprolyl)amino]benzophenone as an auxiliary chiral moiety with alkyl thiocyanates leads to the α-thioalkylated derivatives in a practical ca.70% chemical yield and stereoselectivity (de 80%).
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