Abstract
Starting from a readily available building block, two straightforward diastereoselective approaches to functionalized 3′-methyl-branched carbocyclic nucleoside analogues of neplanocin F and abacavir bearing different purine bases are described. The key steps are a regioselective allylic hydroxylation in the first approach and a ring opening of a cyclic carbonate for the second one, affording allylic alcohols as carbasugar intermediates. In both cases, the carbasugars thus synthesized are then coupled with different purine bases.
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