Abstract
The reduction of aliphatic and aromatic α-keto esters was carried out using a thermophilic actinomycete, Streptomyces thermocyaneoviolaceus IFO 14271, as a biocatalyst. Ethyl 3-methyl-2-oxobutanoate, methyl benzoylformate, and ethyl benzoylformate were reduced to the corresponding ( R)-alcohols with >98% enantiomeric excess (ee) at 37°C, while the reduction in the presence of glutamic acid gave the ( S)-hydroxy esters in excellent ee (>99%). Ethyl 2-oxopropanoate and ethyl 2-oxobutanoate were also reduced to the corresponding ( S)-alcohols with >99% ee in the presence of an amino acid such as asparagine or aspartic acid.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
