Step sequential therapy for treating children with post-renal acute renal failure induced by Ceftriaxone

Abstract

Objective To analyze the clinical characteristics and treatment of post-renal acute renal failure(ARF) induced by Ceftriaxone in children. Methods The clinical data of 7 cases of post-renal acute renal failure in children from June 2012 to June 2014 induced by Ceftriaxone were analyzed.According to the changes in urine volume, serum creatinine, blood urea nitrogen and serum potassium level, liquid therapy, retrograde ureteral catheterization(RUC) and peritoneal dialysis was performed by step sequential therapy respectively. Results Seven cases were given intravenous Ceftriaxone under the fluid loss state.Abdominal pain, sudden anuria or oliguria appeared in the children after 2.6 d on the average, B ultrasonography and CT scanning showed multiple calculus in the bilateral renal pelvis and ureteral calculi.Blood BUN was 15.2-37.9 mmol/L[(23.3±8.6) mmol/L], and blood Cr was 180-636 μmol/L[(378.9±148.4) μmol/L]. These indicators met the diagnostic criteria for acute renal failure.In 7 cases, 2 cases (28.6%) received fluid therapy of sodium bicarbonate alkalization and anisodamine spasmolytic, 4 cases (57.1%) received fluid therapy and RUC, and 1 case (14.3%) underwent fluid therapy and RUC and peritoneal dialysis.All of 7 cases (100%) were alive.In the average 4.4 days renal function of 7 cases was returned to normal, and urine volume and electrolyte were also restored. Conclusions Step sequential therapy including fluid therapy, RUC and peritoneal dialysis is effective with post-renal ARF in children induced by Ceftriaxone. Key words: Ceftriaxone; Acute renal failure, post-renal; Child