Abstract
Neurodegenerative diseases are characterized by neurodegenerative changes or apoptosis of neurons involved in networks, leading to permanent paralysis and loss of sensation below the site of the injury. Cell replacement therapy has provided the basis for the development of potentially powerful new therapeutic strategies for a broad spectrum of human neurological diseases. In recent years, neurons and glial cells have successfully been generated from stem cells, and extensive efforts by investigators to develop stem cell-based brain transplantation therapies have been carried out. We review here notable previously published experimental and preclinical studies involving stem cell-based cell for neurodegenerative diseases and discuss the future prospects for stem cell therapy of neurological disorders in the clinical setting. Steady and solid progress in stem cell research in both basic and preclinical settings should support the hope for development of stem cell-based cell therapies for neurological diseases.
Highlights
Neurodegenerative diseases, such as Parkinson’s disease (PD), stroke, Huntington’s disease (HD)and amyotrophic lateral sclerosis (ALS), are characterized by neurodegenerative changes or apoptosis of neurons involved in networks, leading to permanent paralysis and loss of sensation below the site of the injury [1]
We review the scientific basis of stem cell therapies and discuss their prospects in Parkinson’s disease, Huntington's disease, Alzheimer's disease, Amyotrophic Lateral Sclerosis, stroke and spinal cord injury. In each of these neurodegenerative diseases, we describe the ways in which stem cells might be used to treat these conditions, discussing the prospects and problems of translating laboratory findings into clinically useful therapies
This review has discussed the major issues associated with stem cell therapy by transplantation for neurodegenerative diseases
Summary
Neurodegenerative diseases, such as Parkinson’s disease (PD), stroke, Huntington’s disease (HD). Cell replacement therapy and gene transfer to the diseased or injured brain have provided the basis for the development of potentially powerful new therapeutic strategies for a broad spectrum of human neurological diseases. Human embryonic stem cells (ESCs) and adult stem cells have been coaxed into types of cells that repair neurodegenerative diseases insulation and replace nerve cells in neurodegenerative diseases [3]. The potency of these cells and the relative ease of isolating and expanding them are invaluable properties for clinical application. Steady and solid progress in stem cell research in both basic and preclinical settings should support the hope for development of stem cell-based cell therapies for neurodegenerative diseases
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