Abstract
Stem cell therapy is a promising approach for treatment of peripheral arterial disease. Pluripotent stem cell derivatives and adult stem cells have shown therapeutic benefit in the preclinical setting in restoring blood perfusion, and improving angiogenesis. Toward progression to clinical use, adult stem and progenitor cells such as mononuclear cells, endothelial progenitor cells, and mesenchymal stem cells have been tested in clinical trials. Although the findings between studies vary, the benefit of stem cell therapy has generally been positive. Here we describe the kinds of stem cells and review the benefits of stem cells in the preclinical and clinical setting.
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