Abstract
Stem Cells, Cancer and the Theory of Cancer Stem Cells in Solid Tumours
Highlights
Cancer originally develops from normal cells that have the ability to proliferate irregularly and turn into malignant [1]
With increasing the number of evidence that cancer stem cells exist in a wide range of tumours, it is becoming important to understand the molecular mechanism that regulate self-renewal and differentiation because corruption of genes involved in these pathways likely participates in tumour growth [3]
Solid tumours emerge in organs that acquire stem cell populations
Summary
Cancer originally develops from normal cells that have the ability to proliferate irregularly and turn into malignant [1]. These cancer stem cells have many characteristics similar with normal stem cells, including self-renewal and differentiation [2]. With increasing the number of evidence that cancer stem cells exist in a wide range of tumours, it is becoming important to understand the molecular mechanism that regulate self-renewal and differentiation because corruption of genes involved in these pathways likely participates in tumour growth [3].
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