Abstract
Stem cell therapy (SCT) for Parkinson’s disease (PD) has received considerable attention in recent years. Non-human primate (NHP) models of PD have played an instrumental role in the safety and efficacy of emerging PD therapies and facilitated the translation of initiatives for human patients. NHP models of PD include primates with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism, who are responsive to dopamine replacement therapies, similar to human PD patients. Extensive research in SCT has been conducted to better treat the progressive dopaminergic neurodegeneration that underlies PD. For effective application of SCT in PD, however, a number of basic parameters still need to be tested and optimized in NHP models, including preparation and storage of cells for engraftment, methods of transplantation, choice of target sites, and timelines for recovery. In this review, we discuss the current status of NHP models of PD in stem cell research. We also analyze the advances and remaining challenges for successful clinical translation of SCT for this persistent disease.
Highlights
Parkinson's disease (PD) is a common neurodegenerative disorder that results from progressive loss of dopaminergic (DA) neurons in the substantia nigra of the midbrain
The molecular hallmark of PD is the presence of Lewy bodies (LBs) composed of the alpha-synuclein (α-syn) protein in the substantia nigra and cortical regions of the brain (Dauer & Przedborski, 2003)
Non-human primate (NHP) models of human disease provide exceptional opportunities to advance Stem cell therapy (SCT) by addressing pertinent translational concerns associated with this research, including the application of autologous/allogeneic-induced pluripotent stem cellderived cellular products, immune responsivity, clinical delivery techniques, and evaluation of candidate cell line profiles following transplantation (Wang et al, 2017; Wei et al, 2016)
Summary
Creativecommons. org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited
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