Abstract
Background Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults. The 5-year survival rate of metastatic RCC is only 10%. This study aimed to investigate the expression of stem cell markers (OCT4 and CD133) and annexin A1 (ANXA1) in RCC and their relations to clinicopathological parameters and Ki-67. Materials and methods OCT4, CD133, ANXA1, and Ki-67 expressions were examined immunohistochemically in RCC specimens from 57 patients. Results High CD133 expression in RCC was significantly associated with grades 1and 2 (P=0.001), pT1 and pT2 (P Conclusion A positive significant correlation of OCT4, CD133, and ANXA1 expressions with the important prognostic pathological features in RCC was found. Moreover, ANXA1 is suggested to have a role in survival of cancer stem cells. Thus, these markers may in future become important biomarkers for progression of RCC and may help in stratification of treatment.
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