Abstract
Flash steady state visual evoked potentials (fSSVEPs) were introduced over 80 years ago. In infancy, fSSVEPs may be useful because of their rapid acquisition time and small variability. Few studies proved their utility in clinical setting.1,2. The aim of this study was to evaluate 33 Hz fSSVEPs in children with optic atrophy using standardized visual inspection analysis. Twenty-seven children (mean age 3.9 ± 3.2 years) diagnosed with optic nerve atrophy underwent transient and fSSVEPs in Robert Hollman Foundation. Stimuli consisted of white light flash at 1–33 Hz. Analysis: N1 and P2 waves of TVEP and visual inspection of fSSVEPs for presence/absence of the fundamental response or other harmonics. 3 subjects were excluded because of artifacts. 16/24 patients with abnormal TPEV had absence of fundamental frequency but presence of a subharmonic; 5 patients had an absent or markedly reduced response. All subjects with normal TPEV had absent or markedly reduced fundamental harmonic and presence of a subharmonic. According to Shpak2 fSSVEPs can be useful in differential diagnosis of optic atrophy in children. These preliminary results suggest that the implementation of flash TVEPs methodology with fSSVEPs can provide further diagnostic information and encourage further studies in optic nerve and visual pathways disorders.
Published Version
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