Abstract
Background. Baclofen is a muscle relaxant agent that in toxic doses exhibits symptoms such as depressed mental status, hypotonia, hyporeflexia, and respiratory depression. Seizure is a less common presentation of Baclofen toxicity, especially in pediatric patients. Case Description. The patient was a 4 year-old boy with no previous neurologic disorder who experienced status epilepticus after ingestion of high dose of Baclofen orally. He was treated conservatively and after 8 hours, he became awake in good condition without any abnormal finding in imaging or laboratory tests. Discussion. This case describes some rare clinical presentations of Baclofen toxicity that were seizure and bradycardia in an otherwise-normal pediatric patient which could be managed conservatively.
Highlights
Baclofen is a muscle relaxant agent that in toxic doses exhibits symptoms such as depressed mental status, hypotonia, hyporeflexia, and respiratory depression
Less common symptoms are seizures, coma, apnea, autonomic disturbances, cardiac conduction abnormalities and rhythmic hiccup-like respirations. This case report describes some of the rare clinical presentations of Baclofen toxicity that were seizure and bradycardia in a pediatric patient
Baclofen overdose was expressed by a decreased level of consciousness especially in the presence of cerebral lesions [1,6]
Summary
Baclofen is a muscle relaxant agent that in toxic doses exhibits symptoms such as depressed mental status, hypotonia, hyporeflexia, and respiratory depression. This case describes some rare clinical presentations of Baclofen toxicity that were seizure and bradycardia in an otherwise-normal pediatric patient which was managed conservatively. Baclofen penetrates the blood-brain barrier and at high doses may cause toxic effects. Common symptoms of Baclofen overdose include depressed mental status, hypotonia, hyporeflexia, and respiratory depression [1].
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