Abstract
A new stationary phase (SP) for HPLC, obtained by thermal immobilization of poly(methyloctadecylsiloxane) (PMODS) onto the surface of porous titanized silica particles, is described. Elemental analysis, infrared and 29Si NMR spectroscopies and chromatographic characterization (Engelhardt, SRM 870 and Tanaka tests) were used to investigate the properties and behavior of the new SP. The preparation of the metalized support and the thermal immobilization of PMODS onto the titanized silica produced a SP based on PMODS that showed high values of efficiency (up to 80,000plates/m) and appropriate asymmetry factors. Silica solubility in severe conditions (alkaline mobile phase at pH 10 and high temperature) was somewhat decreased by the presence of titanium on the surface of the support, increasing column lifetime.
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