Abstract
Static magnetic field (SMF) has shown some possibilities for cancer therapies. In particular, the combinational effect between SMF and anti-cancer drugs has drawn scientists’ attentions in recent years. However, the underlying mechanism for the drug-specific synergistic effect is far from being understood. Besides, the drugs used are all conventional chemotherapy drugs, which may cause unpleasant side effects. In this study, our results demonstrate for the first time that SMF could enhance the anti-cancer effect of natural compound, capsaicin, on HepG2 cancer cells through the mitochondria-dependent apoptosis pathway. We found that the synergistic effect could be due to that SMF increased the binding efficiency of capsaicin for the TRPV1 channel. These findings may provide a support to develop an application of SMF for cancer therapy. The present study offers the first trial in combining SMF with natural compound on anti-cancer treatment, which provides additional insight into the interaction between SMF and anti-cancer drugs and opens the door for the development of new strategies in fighting cancer with minimum cytotoxicity and side effects.
Highlights
We aim to investigate the combinational effect of capsaicin and Static magnetic field (SMF), so we choose the concentrations of capsaicin below 100 μM
Our results show that the HepG2 cell proliferation of the SMF treated group did not differ from that of the control group, indicating that SMF alone will not cause inhibition effect on HepG2 cells
For 75 μM capsaicin, which already reduced the viability of HepG2 cells, its inhibition effect was increased by 0.5 T SMF
Summary
The objective of this study was to investigate the synergistic anticancer effect of SMF and capsaicin on HepG2 cells. We aim to investigate the combinational effect of capsaicin and SMF, so we choose the concentrations of capsaicin below 100 μM
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