Abstract
State of art of oral vitamin B12 (cobalamin) treatment in Biermer's disease (pernicious anemia)
Highlights
Vitamin B12 is the largest and most complex of all the vitamins [1]
This narrative review summarizes the current knowledge on the efficacy and safety of oral vitamin B12 treatment in Biermer’s disease
To date in worldwide clinical practice, the majority of patients with vitamin B12 deficiency is treated with parenteral vitamin B12 administration
Summary
Vitamin B12 (cobalamin) is the largest and most complex of all the vitamins [1]. Their molecular structure is C63H88CoN14O14P or C62H88CoN13O14P and their molecular weight is 1329.37 g/mol (Figure 1). It is the only known metabolite to contain cobalt, which gives this water-soluble vitamin its red color This group of corrinoids is known as cobalamins. The main cobalamins in humans and animals are hydroxo-, adenosyl- and methyl- cobalamin, the last two being the active coenzyme forms [2]. These compounds are necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. The treatment is based on cyano- and hydroxo-cobalamin in the form of tablets, injectable or oral solutions This narrative review summarizes the current knowledge on the efficacy and safety of oral vitamin B12 (cobalamin) treatment (replacement) in Biermer’s disease (pernicious anemia)
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