Abstract
Heart rate variability and heart rate under general anesthesia in rats of both sexes
Highlights
The primary objective of this study was to determine the impact of spectral powers of heart rate variability (HRV) on changes in heart rate (HR), total spectral power of HRV, and low-frequency (LF)/high-frequncy (HF) ratio in healthy, sexually mature rats of both sexes spontaneously breathing under zoletil anesthesia in the light and the dark period of their regimen day
The autonomic nervous system was involved in HR changes in both light periods, while in males, HR exhibited no dependence on autonomic nervous system activity; as such, the authors speculate that it was predominantly determined by other factors
HRV was determined by sympathetic and baroreflex activity in both light periods, while in males, HRV was determined by parasympathetic activity
Summary
The primary objective of this study was to determine the impact of spectral powers of heart rate variability (HRV) on changes in heart rate (HR), total spectral power of HRV, and low-frequency (LF)/high-frequncy (HF) ratio in healthy, sexually mature rats of both sexes spontaneously breathing under zoletil anesthesia in the light (inactive) and the dark (active) period of their regimen day. General anesthesia is known to potentiate parasympathetic activity and weaken sympathetic and baroreflex activity [1]. These effects should be avoided as much as possible because it limits a subject's ability to respond to physiological perturbations during surgery [2]. Heart rate (HR) is the result of mutual interactions between vagal and sympathetic activity. In this regard, the use of the HR variability (HRV) method can be an effective tool in evaluating autonomic heart control, in which changes in HRV are a useful indicator of tendencies of heart rhythm disorders. There is no supportive evidence of changes in HRV in rats over a 24 h period
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