Abstract
Methicillin Resistant S. aureus (MRSA) infections are associated with longer hospital stays and increased healthcare costs, heightened morbidity and mortality. Data on the contribution of MRSA to respiratory pathology in Romania is lacking. The aim of this work is to evaluate the profile of S. aureus infections from adult inpatients in the “Marius Nasta” National Institute for Pneumonology (MNNIP). We evaluated the diagnostic yield and antibiotic resistance profile of all S. aureus isolates obtained from respiratory samples in adult patients in MNNIP between the years 2010 and 2013. We surveyed 638 isolates in the MNNIP Bacteriology Laboratory. Of these, 473 unique isolates were included in the analysis. MRSA was diagnosed in 287(60.7%) of samples. Yearly isolates of S. aureus (MRSA%) were as follows: 2010 n=143 (54%), 2011 n=96(65.6%), 2012 n=101 (57.4%), 2013 n=133 (67%). MRSA isolated strains increased between the year 2010 and 2013 (Chi-square two sided p=0.028). No isolate showed resistance to Vancomycin. Only 5 MRSA strains (1.1%) showed resistance for Linezolid. Ceftarolin testing was done in only 39 isolates - 22 (56%) were MRSA, of which 7 (32%) were resistant. A detailed report of the resistance profiles is included. There seems to be an increase in the number of isolates of MRSA over time. MRSA constantly accounts for more than half of isolates. While the number of isolates is inconsistent over time (2010 vs 2011), there is a significant increase in isolation of MRSA (2010 vs 2013). To our knowledge, this is the first report which spans such a significant amount of time from inpatients of a specialized tertiary center from Romania.
Published Version
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