Staphylococci: on the ubiquitous nature of human infections and their control by antimicrobial agents, singly or in combination.

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Article1 January 1958STAPHYLOCOCCI: ON THE UBIQUITOUS NATURE OF HUMAN INFECTIONS AND THEIR CONTROL BY ANTIMICROBIAL AGENTS, SINGLY OR IN COMBINATIONPAUL BUNN, M.D., F.A.C.P., ALDONA BALTCH, M.D., WINIFRED OSBORNE, B.S., LEONARD CANARILI, B.S.PAUL BUNN, M.D., F.A.C.P.Search for more papers by this author, ALDONA BALTCH, M.D.Search for more papers by this author, WINIFRED OSBORNE, B.S.Search for more papers by this author, LEONARD CANARILI, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-1-102 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUnlike the situation in virtually every other human infection caused by cocci, there is now no clearly described best antimicrobial therapy for penicillin-resistant staphylococcal infections. This report is concerned with in vitro studies upon staphylococcal growth as inhibited by eight antimicrobial agents, used singly and in various combinations, and with observations made in the management of 60 cases of serious staphylococcal infections in adults.Prior to 1941 three of four patients with staphylococcal infection complicated by bacteremia died, with the course of disease mostly uninfluenced by antiserum and sulfonamides.1, 2From 1942 until 1946, with the use of penicillin, the...Bibliography1. Anderson DG: Treatment of infections with penicillin, New England J. Med. 232: 400-405 (Apr. 5) 1945. CrossrefGoogle Scholar2. MitchellChapman OWOD: Staphylococcus aureus septicemia, New York State J. Med. 40: 1308-1311 (Sept.) 1940. Google Scholar3. Penicillin in treatment of infections: a report of 500 cases. Statement by the Committee on Chemotherapeutics and other Agents, C. Keefer, Chairman, Division of Medical Sciences, National Research Council, J. A. M. A. 122: 1217-1224 (Aug. 28) 1943. CrossrefGoogle Scholar4. DowlingLepperCaldwellSpies HFMHERHW: Staphylococcic endocarditis: an analysis of 25 cases treated with antibiotics, together with a review of recent literature, Medicine 31: 155-176 (May) 1952. CrossrefMedlineGoogle Scholar5. HansmannKarlish WAJ: Staphylococcal pneumonia, Brit. M. J. 2: 845-847 (Oct. 13) 1956. CrossrefMedlineGoogle Scholar6. KnightCollins VHS: Current view in the problem of drug resistant staphylococci and staphylococcal infections, Bull. New York Acad. Med. 31: 549-568 (Aug.) 1955. MedlineGoogle Scholar7. Rogers DE: The current problems of staphylococcal infections, Ann. Int. Med. 45: 748-781 (Nov.) 1956. LinkGoogle Scholar8. WiseCrannySpink RICWW: Epidemiological studies on antibiotic resistant strains of Micrococcus pyogenes , Am. J. Med. 20: 176-184 (Feb.) 1956. CrossrefMedlineGoogle Scholar9. BunnCanariliOsborne PLW: Activity of certain combinations of antimicrobial agents upon Pseudomonas aeruginosa. Antibiotics Annual 1953-54, pp. 279-284, Medical Encyclopedia, Inc., Publishers, N. Y. C. Google Scholar10. Gots JS: Production of extracellular penicillin-inactivating substances associated with penicillin resistance in Staphylococcus aureus , Proc. Soc. Exper. Biol. and Med. 60: 165-168 (Oct.) 1945. CrossrefMedlineGoogle Scholar11. Osler W: Practice of medicine, 7th Ed., 1909, D. Appleton & Co., New York, p. 215. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Syracuse, N. Y.*Presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 10, 1957.From the State University of New York, Upstate Medical Center, Department of Medicine, Syracuse, N. Y.†Laboratory work supported by a grant from Bristol Laboratories, Inc., Syracuse, N. Y.Requests for reprints should be addressed to Paul A. Bunn, M.D., Department of Medicine, University Hospital of the Good Shepherd, 150 Marshall Street, Syracuse 10, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byResistant Staphylococcic Infections: The Surgical Aspects 1 January 1958Volume 48, Issue 1Page: 102-113KeywordsAntimicrobialsBacteremiaChloramphenicolInfectious diseasesPenicillinResearch laboratoriesSepsisStaphylococcal infection Issue Published: 1 January 1958 PDF downloadLoading ...