Abstract
A rapid, simple method for measuring fibrinogen split products in serum is described. It is based on clumping of staphylococci after serial dilution of test samples on a microtiter plate. The assay can be completed in less than 30 min.; its usual sensitivity is 0.75 μ g. per ml. (in fibrinogen equivalents). The sera of 52 blood bank donors had a range of 0.75 to 9 μ g. per ml. (mean ± , 2.7 ±2.1 ±g. per ml.), with only one value > 6 μ g. per ml. The results by this method were in good agreement with those obtained by a hemagglutination-inhibition method for frozen sera of patients with evidence of the intravascular coagulation and fibrinolysis (ICF) syndrome. Analysis in cases of suspected ICF should be done on fresh sera.
Published Version
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