Abstract

Lymphoepithelioma-like cholangiocarcinoma (LELCC) is a rare variant of intrahepatic cholangiocarcinoma. Epstein-Barr virus (EBV) was reported to be associated with LELCC in approximately 70% of cases by EBV-encoded small non-polyadenylated RNA (EBER) in situ hybridization. In reviewing literature, the treatment experience of advanced LELCC are lacking. In this study, we reported a young female patient diagnosed with locally advanced EBV-associated LELCC with elevated EBV DNA titer and treated with systemic chemotherapy.

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