STANDARDIZATION OF PANCHKOLA CHURNA – A PHARMACEUTICAL AND CHEMICAL STUDY

Abstract

In Ayurvedic classics, many categories of formulations are described, among which Churna is one. Churnas with single or multiple plant-origin drugs as ingredients are narrated in Ayurvedic texts for curing many diseases. The present research work deals with the preparation of Panchkola churna and its analysis for establishing the Pharmacopoeial standard as since now, no tests and measures are being worked out for assuring its quality parameters by the existing Ayurvedic Pharmacopoeial Commission Govt. of India, Ministry of AYUSH. The two batches of this particular Churna are made following the Standard operative process (SOP). The physio-chemical standards of these two batches PC-I & PC-II, were worked out along with TLC & HPTLC. The LOD, Ash Acid Insoluble Ash, Alcohol & water-soluble extractive, and a pH of 10% aqueous solution of the drug were worked out, and a range was established for giving the standards. The shelf-life period was also studied for the above samples concerning the tests and standards compared at 0, 6 and 12-month intervals. It was found that the values of most of the physio-chemical standards remain more or less the same. Still, a massive change in alcohol & water-soluble extractives after 12 months was observed, which signifies that under ordinary packing conditions, it can be kept for 12 months without losing its efficacy. The HPTLC standards at 200nm, 350nm, and 400nm of successive Rf are also worked out for knowing the standards.