Abstract
Oral administration of 5 mg each of deuterium-labeled cortisol ([1,1,19,19,19- 2H 5]cortisol, cortisol-d 5) and cortisone-d 5 ([1,1,19,19,19- 2H 5]cortisone) to a human subject on two different occasions four weeks apart provided a useful means of characterizing the kinetics of the interconversion of cortisol and cortisone. From the data on plasma concentration measurements of cortisol-d 5, cortisone-d 5, endogenous cortisol and endogenous cortisone by gas chromatography-mass spectrometry, it was demonstrated that (1) the plasma concentration ratio of cortisone-d 5 to cortisol-d 5 approached a plateau 4–5 h following either the cortisol-d 5 or cortisone-d 5 administration and the plateau values for the cortisone-d 5 and cortisol-d 5 administration were almost identical (about 0.43) and (2) dosing with only 5 mg of the deuterium-labeled steroids suppressed the plasma concentrations of endogenous cortisol and cortisone.
Published Version
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