Abstract
The utility of isothermal heat conduction calorimetry for the study of stability of pharmaceuticals in solution is demonstrated in this study. The rate of heat evolution is measured as a function of the concentration of ampicillin, pH and the temperature. The pseudo first-order reaction rate constants, k, for the hydrolysis reaction are calculated from the variation of the heat evolution with time. The pH-rate profile for this reaction, as determined from the calorimetric data, is shown to correlate well with the literature data determined by other standard analytical methodology. The molal enthalpy of reaction was also calculated as function of pH and temperature.
Published Version
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